Self-learning AI makes NFL matchup moneyline, over-under and spread picks for every Week 18 matchup, 2025



The final week of the regular season is upon us and Week 18 culminates with a head-to-head battle between the Detroit Lions and the Minnesota Vikings with the NFC North and the No. 1 seed in the NFC playoff standings at stake. The Lions are three-point favorites in the latest Week 18 NFL odds. Meanwhile, there is a playoff spot available in both conferences, with the Broncos (-10.5), Dolphins (-1) and Bengals (- 1.5) competing for the AFC opening and the Buccaneers and Falcons in the race for the NFC South title.

Who should you back in those games with playoff implications and how should you handle your entire NFL moneyline, NFL over-under and NFL against spread picks? Before making Week 18 NFL picks and Week 18 NFL score predictions, you should check out NFL Against the Spread, NFL Over-Under, and NFL Moneyline Predictions Powered by SportsLine Self-Learning AI.

Created with cutting-edge artificial intelligence and machine learning techniques by SportsLine’s data science team, AI predictions and ratings are generated for each game. The AI ​​predictions are determined by statistically learning from each team’s historical data and then quantitatively evaluating the strength of the opponent’s defense by assigning a numerical value out of 100 called the matchup score.

Once a prediction is formulated, the AI ​​score is generated using the prediction, matchup score, and market odds. For example, you might see an A grade on an overbet if a team faces a poor defense, their prediction differs from the line, and there are favorable odds.

Additionally, SportsLine AI is SportsLine’s first fully automated predictive model. It is continually updated with the latest available data and can help you spot the biggest discrepancies in your lines. SportsLine’s AI PickBot has reached a whopping 2,131 4.5 and 5 star accessory picks since the start of last season.

For Week 18 NFL betting, AI PickBot evaluated NFL odds and provided NFL betting picks for all 16 games. You can only see AI’s predictions for the Week 18 NFL schedule here.

Top NFL AI Picks of Week 18

After analyzing every game of Week 18, AI PickBot says the Buccaneers comfortably cover as 13.5-point home favorites against the Saints on Sunday with an over-under of 43.5. The Buccaneers have had the NFC South seesaw several times this season, but are now in the driver’s seat after handily beating the Panthers last week and a Falcons loss to the Commanders.

Rookie running back Bucky Irving became the first Tampa Bay running back to reach 1,000 yards since Doug Martin in 2015, and the one-two punch he formed with Rachaad White has helped provide needed balance to a dynamic Tampa Bay passing attack. The Buccaneers offense has accumulated at least 400 yards of offense in six consecutive games and won five of those games.

Meanwhile, New Orleans has been decimated by injuries and hasn’t reached 20 points or 300 yards in the last month. The Saints have lost their last two games by a combined 49 points and will likely fall short again on Sunday. That’s a big reason why AI PickBot rates a Buccaneers cover as an A-grade pick and predicts a 30-9 win on average. Check out his other Week 18 football predictions and picks at SportsLine.

How to make Week 18 NFL picks

Additionally, AI PickBot has generated 13 highly coveted A+ picks for Week 18. You should check out AI PickBot’s NFL picks before placing your own Week 18 NFL bets. You can only see them at SportsLine.

Who wins and covers every Week 18 NFL game and which A+ picks should you target next? Visit SportsLine now to see the top NFL picks against the spread, over-under and moneyline, all from SportsLine’s self-learning PickBot AI that has produced 2,131 top-rated picks since the start of last season.





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